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. 2008 Jan 31;149(5):2637–2645. doi: 10.1210/en.2007-1096

Figure 6.

Figure 6

FOXO3a regulation of uPA promoter activity. A, WT and mutant (mut) uPA promoter-luciferase constructs. B, Relative luciferase activity after expression of either control pLPCX (white bars), pLPCX-WT-FOXO3a (gray bars), or pLPCX-TM-FOXO3a constructs (black bars). Luciferase data are reported as a mean ± se of triplicate experiments. Asterisk (*) signifies that WT-FOXO3a and TM-FOXO3a increase WT-uPA promoter activity significantly (P < 0.05, using a two-tailed unpaired Student’s t test). Double asterisk (**) signifies that the mutant-uPA promoter has significantly less activity in the context of either the empty pLPCX, WT-FOXO3a, and TM-FOXO3a encoding vectors than the WT promoter (P < 0.05, using a two-tailed unpaired Student’s t test).