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Assessment of working memory performance using the SAB in female 3xTg-AD mice. Data show mean (±sem) percentages of alternations in a Y-maze assessed during an 8-min trial on the day the animals were killed. Both E2 and PPT but not DPN treatment rescued the OVX-induced impairment in SAB, compared with sham OVX [F (4,27) = 9.22, P < 0.0001]. *, P < 0.05, compared with sham OVX group; #, P < 0.05, compared with OVX group.
