Figure 1.

Effects of obesity and triglycerides on three tasks measuring memory. A, Comparison of obese and normal mice in the T-maze foot shock avoidance test. Obese mice performed less well in both measures of cognition. B, Response to foot shock. Obese mice were more sensitive to foot shock than normal mice. C, Comparison of time to reach the platform in the water maze. Obese mice performed more poorly than the normal mice. D, Comparison of acquisition of the lever press task in obese and normal mice. Obese mice performed more poorly than normal mice. E, Effect of triglyceride lowering with gemfibrozil on acquisition in obese mice. Mice with serum triglycerides lowered with gemfibrozil (Gem) performed better than vehicle (Veh)-treated mice. F, Effect of triolein or palmitate injected into the third ventricle on memory in the T-maze foot shock avoidance test. Triolein but not palmitate impaired memory. *, P < 0.05; **, P < 0.01.