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. Author manuscript; available in PMC: 2008 Oct 15.
Published in final edited form as: Arch Biochem Biophys. 2007 Jul 10;466(2):164–171. doi: 10.1016/j.abb.2007.06.027

Figure 8.

Figure 8

Proposed mechanism of the inhibitory action of DOX on oxidation of ABTS by LPO/H2O2. The inhibition is due to reduction of ABTS•+ by the drugs’ hydroquinone moiety forming a DOX-derived semiquinone, which also reacts with ABTS•+. LPO, LPO-I, LPO-II represent the ferric enzyme, and LPO compounds I and II, respectively. Q-QH2, Q-QH• and Q-Q designate redox-active groups of intact doxorubicin, a doxorubicin free radical (quinone-semiquinone form), and the di-quinone form of DOX, respectively.