Table 2.

Factors influencing harm reported in the abstract

	cPR (CI95%)
Funding*
drug or device companies	1
public institutions	0.77 (0.60 to 0.97)
Placebo
other control	1
placebo	0.97 (0.81 to 1.13)
Sample size
less than 20	1
equals or more than 200	1.14 (0.96 to 1.33)
Direction of effect
beneficial to intervention	1
neutral or against the intervention	1.00 (0.83 to 1.19)
Harm in text
no harm in text	1
harm in text	8.71 (5.90 to 12.01)
Clinical significance of harm
no mortality nor composite in text	1
mortality or composite in text	1.43 (1.22 to 1.65)
Harm in text statistically significant
not statistically significant	1
statistically significant	1.70 (1.47 to 1.92)

cPR: Prevalence Ratio estimated by logistic regression, and corrected by applying the method proposed by Zhang [24]; CI: Confidence Intervals with error type I equals 5%; *363 articles except for funding in which sample size was n = 226