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Cryo-TEM of the interaction of hIAPP and mIAPP with LUVs. (a) hIAPP in the presence of LUVs. (b) hIAPP fibrils in the absence of LUVs. (c) mIAPP in the presence of LUVs. Distorted LUVs (asterisks) are in contact with hIAPP fibrils (black arrows). All samples contain 5% DMSO. LUVs are composed of DOPC/DOPS 7:3 with a phospholipid concentration of 7 mM. IAPP concentration is 1 mM. (Scale bars, 200 nm.)
