Table 1.

Uncontrolled Trials of UDCA for Treatment of PSC

Author/Year	No. of Patients	Dose of UDCA/Duration	Biochemical Response	Symptom Improvement	Histologic Response
Podda et al[11] 1989	6	250-750 mg/day 6 months	Yes	NA	NA
Chazouilleres et al[12] 1990	15	750-1250 mg/day 6 months	Yes	NA	NA
O'Brien et al[14] 1991	12	10 mg/kg 30 months with 24 months of treatment	Yes	NA	NA
van Milligan de Wit et al[16] 1999	17	12-15 mg/kg/day 1 year	Yes	NA	NO

UDCA = ursodeoxycholic acid; PSC = primary sclerosing cholangitis; NA = not available