Table 2.

Controlled Trials of UDCA for Treatment of PSC

Author/Year	No. of Patients	Dose of UDCA/Duration	Biochemical Response	Symptom Improvement	Histologic Response
Beuers et al[15] 1992	14	13-15 mg/kg/day 1 year	Yes	No	Yes
Stiehl et al[17] 1994	20	750 mg/day 3 months controlled	Yes	No	Yes
De Maria et al[18] 1996	59	600 mg/day 2 years	No	NA	No
Lindor[19] 1997	105	13-15 mg/kg/day 2.2 years median follow-up	Yes	No	No
van Hoogstraten et al[20] 1998	48	10 mg/kg/day 2 years	Yes	No	No
Okolicsanyi et al[21] 2003	86	8-13 mg/kg/day Retrospective	Yes	Yes	NA

UDCA = ursodeoxycholic acid; PSC = primary sclerosing cholangitis; NA = not available