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Genomic DNA sequence of the junction of NPM1 intron 11 and exon 12. Intronic residues are in lower case. The NPM1 wild-type stop codon is underlined. The vertical arrow indicates the site of tetranucleotide insertion for the most common mutation types. The type A mutation results in the duplication of the preceding TCTG sequence. Regions of PCR primer binding are shown in bold. The dotted line indicates the area where insertions and insertion/deletions in AML have been observed.6
