Table 2.
MRM porB VR Genotype Profiles of N. meningitidis Serotyped Strains
|
porB |
||||||
|---|---|---|---|---|---|---|
| Serotype | PorB class | No. tested | VR1 | VR2 | VR3 | VR4 |
| 1 | 3 | 1 | 19 | Ac | 7a | 1 |
| 1 | 3 | 1 | 19 | Ac | 341 | 1 |
| 4 | 3 | 8 | 4 | D | 7 | 14a |
| 4 | 3 | 1 | 4 | B | 7 | 14a |
| 4 | 3 | 1 | [4] | B | 7 | 14a |
| 4 | 3 | 1 | [4] | D | 7 | 14a |
| 4 | 3 | 1 | 4 | Db | 7 | 14a |
| 4 | 3 | 1 | 4 | B | 7 days | 14a |
| 14 | 3 | 3 | 19 | B | 7c | 14 |
| 2a | 2 | 4 | C | Eb | 2a | C |
| 2a | 2 | 1 | Cb | Eb | 2a | C |
| 2b | 2 | 1 | C | Ea | 2b | C |
| 2b | 2 | 1 | C | Near Ea* | 2b | C |
| 15 | 3 | 1 | A | A | A | Ba |
| 21 | 3 | 1 | 4 | D | 7b | 21 |
| 21 | 3 | 1 | 329 | 313 | 7b | 364 |
| 22 | 2 | 2 | C | Ed | 5a | Db |
| 22 | 2 | 1 | C | Undefined† | Near 5a‡ | Near Ca§ |
Four samples that gave atypical variant profiles for the serotype are in bold type.
*
Single-nucleotide polymorphism at position 35 (C to T) amino acid change alanine to valine.
†
DNA sequence AACAATGATGCAAAACGTGTTGCAGTAGGTACTGACAATCCTGTT amino acid sequence NNDAKRVAVGTDNPV.
‡
polymorphisms at positions 9 to 11 (GAT to ACC) with an amino acid change from aspartic acid to threonine.
§
single-nucleotide polymorphism at Ca position 2 (T to A) with an amino acid change from valine to glutamic acid.