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. 2008 May;172(5):1195–1208. doi: 10.2353/ajpath.2008.070207

Figure 2.

Figure 2

IL-13-deficient mice develop severe myocarditogenic peptide-induced myocarditis. A: Representative EAM in an IL-13 KO mouse. B: Representative EAM in a WT BALB/c mouse. C: The differences in the EAM severity in IL-13 KO mice (filled diamonds) were highly significant, compared to WT BALB/c mice (open diamonds) at day 21 after infection. Data represent individual animals, and are representative of five repetitions with 8 to 14 mice per group. Statistics are by Mann-Whitney rank sum U-test. D: Total cardiac-infiltrating CD45+ leukocytes, as calculated by flow cytometry and manual enumeration. E: IL-13 KO mice (filled bars, n = 12) had increased MyHCα614–629-reactive serum antibodies compared to WT BALB/c control mice (open bars, n = 11) at day 21 after infection. Statistics are by two-tailed Student’s t-test. F: Blocking IL-13 with αIL-13 mAb increased severity of EAM, compared to isotype-treated control. Original magnifications: ×5 (A, B; left) and ×64 (A, B; right).