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. 2008 May;172(5):1195–1208. doi: 10.2353/ajpath.2008.070207

Figure 5.

Figure 5

A: IL-4-deficient mice develop mild MyHCα614–629-induced myocarditis (filled diamonds), comparable to WT BALB/c mice (open diamonds). Data represent individual animals, and three repetitions with 8 to 10 mice per group. B: There were no differences in levels of intracardiac IL-1β, IL-13, IL-18, or IFN-γ between IL-4 KO (filled bars, n = 8) and WT BALB/c control mice (open bars, n = 8) at day 21 after infection of EAM as determined by ELISA. Statistics are by two-tailed Student’s t-test. Data are normalized to wet heart weight. MyHCα614–629-reactive serum antibodies by subclass: total IgG (C), IgG1 (D), IgG2a (E), IgG2b (F). IL-4 KO (filled bars, n = 8) had higher levels of IgG2a and IgG2b MyHCα614–629-reactive serum antibodies than WT BALB/c control mice (open bars, n = 8) at day 21. G: Similar to IL-4 KO mice, we did not observe any differences in EAM severity after treatment with anti-IL-4 mAb, compared to isotype-treated controls. Severity statistics are by Mann-Whitney U-test.