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. 2008 May;172(5):1195–1208. doi: 10.2353/ajpath.2008.070207

Figure 6.

Figure 6

A: IL-13/IL-4 DKO mice (filled diamonds) develop myocarditis resembling severe IL-13 KO EAM, which was significantly greater than myocarditis severity in WT BALB/c control mice (open diamonds) at day 21 after infection. Data represent individual animals. Individual experiments were conducted five times with 8 to 14 mice per group. B: Intracardiac IL-18 was significantly increased in IL-13/IL-4 DKO mice compared to WT BALB/c mice at day 21 after infection of EAM as determined by ELISA. Data are normalized to wet heart weight. C: Total IgG MyHCα614–629-reactive serum antibodies and its subclasses IgG2a and IgG2b were significantly increased in IL-13/IL-4 DKO (filled bars, n = 8), compared to WT BALB/c control mice (open bars, n = 8) at day 21 after infection. IgG1 was significantly decreased in IL-13/IL-4 DKO mice. D: CD4+CD25+Foxp3+ T cells were decreased in IL-13/IL-4 DKO spleens (filled diamonds), compared to WT BALB/c control mice (open diamonds) at day 21 of EAM. Statistics are by two-tailed Student’s t-test.