Figure 4.

Effects of hematopoietically expressed PrP-Fc₂. a: PrP-Fc₂ titers (relative units) in blood of chimeric mice. tg588→wt reconstituted mice showed weaker PrP-Fc₂ expression than tg588 mice. b: Fifty days after RML prion inoculation, spleens from tg588→wt and wt→ tg588 showed decreased accumulation of PrP^Sc compared to wt→wt spleens. c: Infectivity titer of wt→ tg588 (n = 1) was below detectability and those of tg588→wt (n = 2) were 1.2 log lower than wt→wt (n = 2, average is represented) controls. d: wt→wt and tg588→wt reconstituted mice succumbed to scrapie at the same stage, whereas wt→ tg588 and tg588→ tg588 mice were retarded.