Figure 5.

Protection against scrapie can be mediated both by neuronally and glially restricted expression of PrP-Fc₂. a–f: Survival plots of scrapie-infected transgenic mice expressing PrP-Fc₂ in the entire CNS (a, b), in astrocytes (c, d), or in oligodendrocytes (e, f) after intracerebral (a, c, e) or intraperitoneal RML prion inoculation (b, d, f). Expression of PrP-Fc₂ in oligodendrocytes, which are inherently resistant to scrapie, delayed prion disease, suggesting a noncell autonomous antiprion effect. g: Immunoblot analysis revealed reduced levels of PrP^Sc in brains of transgenic mice expressing PrP-Fc₂ cells specifically. h: GFAP staining indicated diminished pathological changes, in agreement with delayed disease progression.