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. 2008 May;172(5):1332–1341. doi: 10.2353/ajpath.2008.071042

Figure 5.

Figure 5

Differential expression of dystrophin and the DGC in skeletal muscle of 6-month-old BL6, mdx3cv, and mdx4cv mice. A: Representative photomicrographs of immunofluorescence staining with epitope-specific antibodies that recognize different regions of dystrophin. N, dystrophin N-terminal domain; R4-6, dystrophin rod domain spectrin-like repeats 4 to 6; R11, dystrophin rod domain spectrin-like repeat 11; R19/H3, dystrophin rod domain spectrin-like repeats 19 and hinge 3; C, dystrophin C-terminal domain. B: Left, relative fluorescence signal intensity. AU, artificial unit. n = 15 for BL6, n = 12 for mdx3cv, and n = 9 for mdx4cv. Right, Representative Western blot with an anti-dystrophin C-terminal antibody. C: Representative photomicrographs of immunofluorescence staining with antibodies against selective components of the DGC. βDG, β-dystroglycan; βSG, β-sarcoglycan; Syn, syntrophin; Dbr, dystrobrevin. Arrowhead, neuromuscular junction.