Figure 10.

Morris water maze analysis. A: Memory impairment comparison of APP/ΔPS1-Tg mice at 3 and 8 months (mon) of age (^#P < 0.001). B and C: Each group of mice overexpressing hNEP (Lenti-hNEP) or GFP (Lenti-GFP) were tested on the 4th day of training for spatial learning (B and C) and memory retention (D and E). To test the mice for spatial learning, the escape latency (B), and total distance (C) taken by both groups of mice to reach the hidden platform were measured. To test for memory impairment (working memory retention), both groups of mice were tested for the percentage of time spend in the NE quadrant (D) and the percentage of time spent in the outer annular (around the wall of the tank) (E) after the hidden platform was removed (*P = 0.0031, **P = 0.0077, ***P = 0.0013, ****P < 0.0001). Morris water maze analysis was accomplished by the SMART video tracking system.