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Immunohistochemistry validation analysis of cross-species conserved genes. Human (colorectal polyps and normal mucosa from FAP patients carrying germline APC mutations) and mouse (duodenal adenomas and normal mucosa from inbred C57BL6/J Apc+/1638N and Apc+/+ mice) tissue sections were analyzed with specific antibodies (see Materials and Methods) for expression of the following proteins: ANXA1 (a–d), CCNA2 (e–h), MARCKSL1 (i–l), and CD44 (m–p).
