Table 4.
The 49-Gene Signature Based on Statistically Significant Differences (FDR = 0.5%) Between Expression Profiles of FAP- and MAP-Derived Adenomatous Polyps, After Implementation of the Mixed-Effect Regression Model34 Fitted Considering Mutation (APC vs. MYH) as Having Fixed Effect and Patient as Having a Random Effect
| GenBank | Gene symbol | Gene description |
|---|---|---|
| H41285 | GDPD2 | Glycerophosphodiester phosphodiesterase domain containing 2 |
| T46878 | EIF3S1 | Eukaryotic translation initiation factor 3, subunit 1 alpha |
| AA479795 | ISG20 | Interferon-stimulated exonuclease gene |
| AA151214 | G3BP2 | Ras-GTPase activating protein SH3 domain-binding protein 2 |
| H28091 | PMP22 | Peripheral myelin protein 22 |
| N59330 | NUP35 | Nucleoporin |
| H19333 | LOC285550 | Hypothetical protein LOC285550 |
| AA449688 | FLJ32065 | Hypothetical protein FLJ32065 |
| N/A | N/A | — |
| AA977417 | AA977417 | — |
| N50636 | RAP1GDS1 | RAP1, GTP-GDP dissociation stimulator 1 |
| T61866 | IPO7 | Importin 7 |
| AA453435 | LTV1 | LTV1 homolog (S. cerevisiae) |
| N91962 | EEF1E1 | Eukaryotic translation elongation factor 1 epsilon 1 |
| H77636 | CD68 | CD68 antigen |
| AI308916 | PRSS3 | Protease, serine, 3 (mesotrypsin) |
| AA478589 | APOE | Apolipoprotein E |
| AA459401 | KLK10 | Kallikrein 10 |
| AA625765 | DDA1 | DDA1 |
| AA205665 | SET | SET translocation (myeloid leukemia-associated) |
| AA707453 | FLJ43855 | Similar to sodium- and chloride-dependent creatine transporter |
| AA464147 | CARS | Cysteinyl-tRNA synthetase |
| AA456630 | ARHGEF18 | Rho/rac guanine nucleotide exchange factor (GEF) 18 |
| N20475 | CTSD | Similar to RIKEN cDNA 6330512M04 gene (mouse) |
| N31935 | ANGPTL1 | Angiopoietin-like 1 |
| R77512 | PCDH1 | Protocadherin 1 (cadherin-like 1) |
| N31492 | FMO4 | Topoisomerase (DNA) I pseudogene 1 |
| N45236 | KIAA0114 | KIAA0114 gene product |
| H60549 | CD59 | CD59 antigen, complement regulatory protein |
| AA907626 | KIF26B | Kinesin family member 26B |
| AA917374 | TIMP2 | TIMP metallopeptidase inhibitor 2 |
| AA983530 | VNN1 | Vanin 1 |
| N90109 | NCL | U23 small nucleolar RNA |
| H15431 | POLR2D | Polymerase (RNA) II (DNA directed) polypeptide D |
| H52673 | BAK1 | BCL2-antagonist/killer 1 |
| T72259 | CYP2A6 | Cytochrome P450, family 2, subfamily A, polypeptide 6 |
| AA455910 | F2R | Coagulation factor II (thrombin) receptor |
| AA775840 | C9orf123 | Chromosome 9 open reading frame 123 |
| AA464566 | LRP1 | Low density lipoprotein-related protein 1 |
| AA489640 | IFIT1 | Interferon-induced protein with tetratricopeptide repeats 1 |
| AA962541 | LOC286167 | Hypothetical protein LOC286167 |
| AA464421 | PCGF2 | Polycomb group ring finger 2 |
| H25761 AI668603 | — | — |
| AA447748 | DLD | Dihydrolipoamide dehydrogenase |
| AA278755 | CEP27 | Centrosomal protein |
| AI261833 | SLC7A9 | Solute carrier family 7 (cationic amino acid transporter, y+ system) member 9 |
| H72802 | ESPN | Espin |
| AA608713 | C1QDC1 | C1q domain containing 1 |
| AA047465 | SLC6A8 | Solute carrier family 6 (neurotransmitter transporter, creatine), member 8 |