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. 2008 Jan 30;9(4):574–587. doi: 10.1111/j.1600-0854.2008.00701.x

Figure 6. Autophagosomes move bidirectionally towards and away from the nucleus dependent on microtubules.

Figure 6

A) Autophagosomes are distributed with a bias towards the MTOC. Scale bar represents 10 μm. B) Fast autophagosome movement towards the nucleus (N) (arrowheads). Scale bar represents 5 μm. C) Fast autophagosome movement away from the nucleus (N) (arrowheads). Scale bar represents 5 μm. D) Fast movements with a velocity above 0.1 μm/second are abolished by microtubule depolymerization by nocodazole. E) Microtubule-dependent movements (i.e. velocity ≥ 0.1 μm/second) are biased towards the nucleus [p = 0.02 (chi-squared test), cumulative result from six cells, 10 vesicles each].