Table 1.
Differential Expression of Multiple Wnt Pathway Genes during Rod and Cone Photoreceptor Degeneration in rd1 Mice (on a C57B1/6 Background) Compared with wt C57B1/6 Mice
| Gene | P14 QPCR rd1/wt Ratio Rod Death | P50 QPCR rd1/wt Ratio Cone Death |
|---|---|---|
| Wnt5a | 1.4* | 4.7 |
| wnt5b | 1.9* | 2.9* |
| Wnt10a | ND in B16 | 1.1 |
| wnt13 | 1.11 | 0.82 |
| SFRP1 | 0.3* | 0.5* |
| SFRP2 | 2* | 1.8* |
| SFRP3 | 2.2* | 2.9* |
| SFRP4 | 0.94 | 2.3* |
| Frizzled3 | 1.2 | 2.5* |
| Frizzled4 | 0.18 | 0.11* |
| Frizzled6 | 2.45* | 1.6 |
QPCR ratios of rd1 to wt expression are shown. ND, not detected.
*
P < 0.05, Student's t-test.