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. 2008 Apr 3;5:12. doi: 10.1186/1742-2094-5-12

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Copyright © 2008 Chen et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Double staining of IgG extravasation and microglia. (A) In addition to microglia, lectin staining also reveals blood vessels. Cholesterol-enriched diet markedly increased the numbers of microglia (green, arrow heads) and IgG extravasation (red). These effects were blocked by caffeine at the dose of 3 mg/day for 12 weeks. Representative images taken from 2 rabbits in each group with 6 sections from each animal are shown. Bar = 50 μm. (B) In a magnified view of the white boxes as shown in panel A, increased microglia (arrow heads) are co-distributed with perivascular immunopositive IgG staining (arrows) in olfactory bulb from cholesterol-fed rabbits. Bar = 20 μm.