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. 2008 Apr 23;14:691–705.

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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comparison of promoter regulated gene expression in rat (wMC) and human (MIO-M1) Müller cells. Müller cells were transfected with 500 bp or 500+UTR genomic DNA constructs (mouse) from each of the nine genes analyzed. Expression was more robust in rat Müller cells (red bars) when compared with human MIO-M1 Müller cells (blue bars), although the trends in promoter-driven transgene expression are similar between species and within genes. Bars indicate fold change in number of eGFP positive cells, normalized to the promoter-less parent vector (pFTM3GW). The mean fluorescence intensity (MFI) for each construct was also normalized to the parent vector (pFTM3GW) and is shown immediately below each bar (shown in orange). Refer to Appendix 1 for genomic coordinates of each construct. Error bars represent 1 standard deviation.