Figure 6. Dynamics of changes in monocyte and osteoclast numbers predicted by the mathematical model.

A, B) Simulation of changes in monocyte number (A) and osteoclast number (B) obtained using the two-species model described by the equations (4–5), with the following parameters: k ₁ = 0.2; 0.4; 0.6; 0.8; 1; 1.2; k ₃ = 0.1; k ₅ = 300; k ₆ = 0; k ₈ = 0.3; n = 8. C, D) Simulation of changes in monocyte number (C) and osteoclast number (D) obtained using the three-species model described by the equations (7–9), with the following parameters: k ₁ = 1; k ₃ = 0.1; k ₅ = 300; k ₆ = 0.5; k ₈ = 0.3; k ₉ = 1; k ₁₀ = 1; k ₁₁ = 0.5; n = 8