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. Author manuscript; available in PMC: 2009 Mar 15.
Published in final edited form as: Bioorg Med Chem. 2007 Dec 10;16(6):3283–3290. doi: 10.1016/j.bmc.2007.12.010

Scheme 1. Reagents and conditions.

Scheme 1

(a) references 40–42; (b) RNH2, CH2Cl2 (anh.), rt, 30 min; (c) (conc.) HCl, reflux, 24h, 94% for 14, 94% for 15, 98% for 16, 85% for 17, 91% for 18, 78% for 19, 88% for 20, 71% for 21, 66% for 22, 79% for 23, 80% for 24, 68% for 25, 77% for 26, 84% for 27.