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. 2008 Feb 5;36(6):1813–1825. doi: 10.1093/nar/gkn015

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© 2008 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Indirect pathways for Sec-tRNA^Sec formation. In all known Sec-decoding organisms, first SerRS aminoacylates tRNA^Sec with Ser to form Ser-tRNA^Sec. In Sec-decoding bacteria, the Ser bound to the tRNA is directly converted to Sec in the presence of selenophosphate by SelA to form Sec-tRNA^Sec. In Sec-decoding eukaryotes and Archaea, the Ser-moiety on tRNA^Sec is first phosphorylated by PSTK to form Sep-tRNA^Sec. The Sep bound to the tRNA is then converted to Sec in the presence of selenophosphate by SepSecS to form Sec-tRNA^Sec.