Figure 1.

C-terminal charge of p53 and p73 isoforms. Shown are the domain structure and C-terminal charge distribution of p53, the p73 isoforms p73α, β, γ and δ, the CTD-deleted p53Δ30 and the p53/p73 chimera p73α+30. C-terminal regions in p73β, γ and δ that differ from the sequence in p73α are shaded in dark grey. The percentage of conserved residues in the transactivation (TA), DNA binding core (DBD) and oligomerization (OD) domain of p53 and p73 is shown. The calculated isoelectric points (pI values) of the total protein, the C-terminus (CT) and the last 30 amino acids are shown in the table for each protein. In the case of p73, CT is defined as the sequence C-terminal to the conserved oligomerization domain.