Figure 4.

Active site region of catalytic antibody 17E8 based upon the crystallographic structure of 17E8 bound to hapten (19). Key residues in proximity to the phosphonate moiety are depicted in addition to Tyr-100a_H. Potential hydrogen bonds or ionic interactions are shown by dotted lines, along with distances in angstroms. All atoms of residue Tyr-100a_H are at least 11 Å away from any hapten atom. Heteroatoms are shown in blue (nitrogen), red (oxygen), or pink (phosphorus), and the heavy chain CDR-H3 (residues 95_H–102_H) is shown by the white ribbon.