Table 2.
BMC of transgenic and control mice
| Genotype | n | Weight, g | Water
|
Lipid
|
Lean body mass
|
|||
|---|---|---|---|---|---|---|---|---|
| Total, g | % | Total, g | % | Total, g | % | |||
| L2 | 5 | 25.6 ± 4.4 | 17 ± 3 | 67 ± 2 | 1.7 ± 0.3 | 7 ± 1 | 7 ± 1 | 27 ± 1 |
| L0-MCK | 6 | 24.6 ± 2.1 | 16 ± 2 | 67 ± 2 | 1.6 ± 0.4 | 7 ± 1 | 7 ± 1 | 27 ± 2 |
| L2-MCK | 7 | 25.9 ± 2.3 | 17 ± 1 | 67 ± 1 | 1.7 ± 0.3 | 7 ± 1 | 7 ± 1 | 27 ± 1 |
| L2-MCK-ob/ob | 5 | 67 ± 3 | 26 ± 3 | 39 ± 4 | 29 ± 5 | 43 ± 6 | 13 ± 1 | 19 ± 2 |
| L0-MCK-ob/ob | 4 | 52 ± 7a | 27 ± 5 | 51 ± 2a | 13 ± 0b | 26 ± 4 | 12 ± 2 | 22 ± 2c |
Two sets of animals were analyzed as described (6). L2, L2-MCK, and L0-MCK made up one group of littermates (3–4 months of age). L2-MCK-ob/ob and L0-MCK-ob/ob mice made up the second set (9 months of age). a, P < 0.005 (vs. L2-MCK-ob/ob), b, P < 0.0005 (vs. L2-MCK-ob/ob); c, P < 0.05 (vs. L2-MCK-ob/ob).