Figure 3.

The coenzyme-binding pockets with ‘excluded’ and ‘binding’ conformers of bound cofactors. The NMN parts of ‘excluded’ conformers cannot be defined except for the bridging pyrophosphate groups. (a) TtP5CDh–NAD with bound NAD⁺: the ‘excluded’ conformer is colored cyan. (b) TtP5CDh–NADH with bound NADH. It does not have a ‘binding’ conformer, only ‘excluded’ conformers (colored cyan and magenta). (c) TtP5CDh–NADP with bound NADP⁺: the ‘excluded’ conformer in TtP5CDh–NAD is superimposed (colored by cyan) and the 2′-phosphate group (except for the bridging O atom) of NADP⁺ is shown as sticks and VdW spheres.