Table 4.
Top functions associated with significant networks identified by IPA and number of focus genes at each time point.
| Top functions | Time | |||
| T1 | T2 | T4 | T8 | |
| Gene Expression | 9 | 12 | 178 | 297 |
| Molecular Transport | 9 | - | 81 | 372 |
| Drug Metabolism | 9 | - | 31 | 83 |
| Cancer | - | 47 | 386 | 357 |
| Connective Tissue Development and Function | - | 27 | 103 | 152 |
| Cell Cycle | - | 24 | 246 | 432 |
| Cellular Development | - | 23 | 144 | 64 |
| Cell Death | - | 23 | 141 | 205 |
| Cell Morphology | - | 23 | 91 | 58 |
| Cellular Movement | - | 15 | 92 | 125 |
| Cellular Assembly and Organization | - | 15 | 82 | 358 |
| Post-Translational Modification | - | 13 | 75 | 79 |
| Small Molecule Biochemistry | - | 13 | 64 | 324 |
| Amino Acid Metabolism | - | 13 | 56 | 219 |
| Neurological Disease | - | 12 | 59 | 147 |
| Organismal Injury and Abnormalities | - | 12 | 30 | 56 |
| Cellular Growth and Proliferation | - | 11 | 93 | 114 |
| Connective Tissue Disorders | - | 11 | 15 | 21 |
| Cell Signaling | - | - | 223 | 662 |
| DNA Replication Recombination and Repair | - | - | 183 | 194 |
| Genetic Disorder | - | - | 128 | 218 |
| Nervous System Development and Function | - | - | 98 | 166 |
| Hematological Disease | - | - | 92 | 89 |
| Protein Synthesis | - | - | 88 | 204 |
| Dermatological Diseases and Conditions | - | - | 82 | 175 |
| Hematological System Development and Function | - | - | 81 | 116 |
| Lipid Metabolism | - | - | 79 | 363 |
| Cell-To-Cell Signaling and Interaction | - | - | 76 | 122 |
| Skeletal and Muscular Disorders | - | - | 76 | 33 |
| Immune Response | - | - | 71 | 246 |
| Cardiovascular Disease | - | - | 70 | 80 |
| Cellular Function and Maintenance | - | - | 61 | 263 |
| Embryonic Development | - | - | 54 | 180 |
| Endocrine System Development and Function | - | - | 53 | 62 |
| Immunological Disease | - | - | 44 | 54 |
| RNA Post-Transcriptional Modification | - | - | 43 | 122 |
| Nucleic Acid Metabolism | - | - | 39 | 130 |
| Reproductive System Development and Function | - | - | 35 | 26 |
| Tissue Development | - | - | 34 | 73 |
| Protein Trafficking | - | - | 34 | 63 |
| Protein Folding | - | - | 32 | 31 |
| Carbohydrate Metabolism | - | - | 31 | 136 |
| Cardiovascular System Development and Function | - | - | 31 | 127 |
| Organismal Development | - | - | 29 | 30 |
| Cellular Compromise | - | - | 28 | 96 |
| Organ Morphology | - | - | 28 | 91 |
| Vitamin and Mineral Metabolism | - | - | 27 | 61 |
| Skeletal and Muscular System Development and Function | - | - | 25 | 33 |
| Developmental Disorder | - | - | 18 | 33 |
| Inflammatory Disease | - | - | 16 | 95 |
| Nutritional Disease | - | - | 16 | 30 |
| Infectious Disease | - | - | 14 | 65 |
| Metabolic Disease | - | - | 12 | 89 |
| Viral Function | - | - | 61 | - |
| Reproductive System Disease | - | - | 48 | - |
| Ophthalmic Disease | - | - | 32 | - |
| Hair and Skin Development and Function | - | - | 31 | - |
| Organ Development | - | - | 31 | - |
| Cardiac Fibrosis | - | - | 30 | - |
| Viral Infection | - | - | 30 | - |
| Cardiac Enlargement | - | - | 28 | - |
| DNA Replication | - | - | 20 | - |
| Cardiac Pulmonary Embolism | - | - | 17 | - |
| Dermatological Diseases and Condition | - | - | 17 | - |
| Cardiac Necrosis/Cell Death | - | - | 16 | - |
| Digestive System Development and Function | - | - | 16 | - |
| Hepatic System Disease | - | - | 14 | - |
| Tumor Morphology | - | - | 13 | - |
| Protein Degradation | - | - | - | 119 |
| Energy Production | - | - | - | 84 |
| Gastrointestinal Disease | - | - | - | 65 |
| Behavior | - | - | - | 61 |
| Immune and Lymphatic System Development and Function | - | - | - | 61 |
| Renal Necrosis/Cell Death | - | - | - | 33 |
| Renal and Urological System Development and Function | - | - | - | 32 |
| Endocrine System Disorders | - | - | - | 31 |
| Cardiac Hypertrophy | - | - | - | 30 |
| Organismal Survival | - | - | - | 28 |
| Free Radical Scavenging | - | - | - | 27 |
| Respiratory System Development and Function | - | - | - | 25 |
| Tissue Morphology | - | - | - | 23 |
| Hepatic System Development and Function | - | - | - | 21 |
| Focus genes | 12 | 98 | 1474 | 2887 |
*The same focus gene may exist in different top functions.
§ The number of focus genes from the Qiagen_NRSP8 microarray is reported at each time point for each top function.