Table 4.
Gene sets highly ranked across platforms. For each platform, gene sets were ranked by their association with the phenotype under study, using the p-value from the global test. Displayed are those gene sets that rank highly in the majority of platforms; for GO sets, the sum of the highest three (out of five) ranks had to be below 100; for KEGG sets, the sum of the highest four (out of five) ranks had to be below 100. Columns 1 and 2 display GO/KEGG IDs and names of the gene sets (in parentheses: GO classification: BP = biological process; MF = molecular function). Columns 3 to 7 display the ranks of the gene sets for each of the platforms.
GENE SET ID | Name | ABI | AFF | AGL | ILL | LGTC |
GO | ||||||
GO:0007214 | gamma-aminobutyric acid signaling pathway (BP) | 232 | 46 | 23 | 26 | 33 |
GO:0004890 | GABA-A receptor activity (MF) | 248 | 42 | 11 | 13 | 48 |
GO:0016917 | GABA receptor activity (MF) | 283 | 40 | 14 | 12 | 52 |
GO:0030594 | neurotransmitter receptor activity (MF) | 433 | 23 | 2 | 2 | 166 |
GO:0042165 | neurotransmitter binding (MF) | 474 | 22 | 1 | 1 | 174 |
GO:0006821 | chloride transport (BP) | 853 | 17 | 3 | 22 | 21 |
GO:0015698 | inorganic anion transport (BP) | 1022 | 7 | 21 | 33 | 76 |
GO:0005230 | extracellular ligand-gated ion channel activity (MF) | 1672 | 29 | 10 | 17 | 91 |
GO:0006820 | anion transport (BP) | 1801 | 8 | 33 | 34 | 98 |
GO:0015276 | ligand-gated ion channel activity (MF) | 1900 | 20 | 4 | 11 | 175 |
GO:0050900 | leukocyte migration (BP) | 13 | 898 | 12 | 69 | 1726 |
KEGG | ||||||
4080 | Neuroactive ligand-receptor interaction | 25 | 1 | 3 | 2 | 10 |
4512 | ECM-receptor interaction | 18 | 9 | 21 | 16 | 33 |
2010 | ABC transporters – General | 27 | 3 | 15 | 4 | 53 |
4660 | T cell receptor signaling pathway | 23 | 16 | 57 | 8 | 31 |
760 | Nicotinate and nicotinamide metabolism | 58 | 8 | 4 | 161 | 20 |
3030 | DNA polymerase | 9 | 11 | 12 | 24 | 138 |
4514 | Cell adhesion molecules (CAMs) | 39 | 13 | 23 | 17 | 115 |
900 | Terpenoid biosynthesis | 13 | 12 | 54 | 19 | 62 |
4640 | Hematopoietic cell lineage | 64 | 4 | 22 | 9 | 76 |