Table 1.
Tissues sampled
| Group | Tissue | Abbreviation | Embryonic origin | Function, remarks | Sampling details | # Extreme Probesa | Principal KEGG pathways of extreme probes |
| Brain | Olfactory bulb | OLFB | Ectoderm (neural) | Perception of odors | Whole organ from both sides | 274 | Neuroactive ligand-receptor interaction WNT signalling pathway |
| Hypothalamus | HYPT | Ectoderm (neural) | Regulates metabolic processes and other activities of the Autonomic Nervous System | Including mammilary body and grey tubercle | 147 | Neuroactive ligand-receptor interaction Cell adhesion molecules (CAMS) | |
| Pineal gland | PING | Ectoderm (neural) | Production of melatonin | Whole gland | 89 | - | |
| Adenohypophysis | AHYP | Ectoderm (stomodeum) | Hormone secretion regulating endocrine glands | Whole gland | 241 | Neuroactive ligand-receptor interaction | |
| Neurohypophysis | NHYP | Ectoderm (neural) | Store and liberation of hormones synthesized by the hypothalamus | Whole gland | 130 | WNT signalling pathway | |
| Endocrine | Adrenal cortex | ADGC | Mesoderm | Synthesis of corticosteroid hormones | Part of the gland after mechanical separation | 14 | - |
| Adrenal medulla | ADGM | Ectoderm (Neural crest) | Synthesis of adrenaline and noradrenalin | Part of the gland after mechanical separation | 12 | - | |
| Thyroid gland | THYG | Endoderm + Ectoderm (neural crest) | Production of thyroxine (T4), triiodothyronine (T3), and calcitonin | Part of the gland | 376 | - | |
| Structural | Diaphragm muscle | DIAP | Mesoderm | Predominant oxidative metabolism | Samples from left and right crura | 166 | Oxidative phosphorylation ATP synthesis Glycolysis Citrate cycle Piruvate metabolism |
| M. Biceps femoris | BIFE | Mesoderm | Glycolitic metabolism | Lateral area of the muscle | 354 | Glycolysis Insulin signalling pathway Frutose and manose metabolism Starch and sucrose metabolism Pentose phosphate pathway | |
| Back fat tissue | FATB | Mesoderm | Fat | Fat from lumbar region | 51 | - | |
| Abdominal fat tissue | FATA | Mesoderm | Fat | Fat external to the rectus sheath | 21 | - | |
| Metabolic | Stomach | STOM | Endoderm | Digestion | Epithelium from the body | 156 | Tight junction |
| Liver | LIVR | Endoderm | Central role in metabolism | Parts from quadrate and left lateral lobes | 824 | Urea cycle Bile acid biosynthesis Biosynthesis of steroids Complement and coagulation cascades Fatty acid metabolism Propanoate metabolism Amino acids metabolisms Butanoate metabolism Metabolism of xenobiotics by cytochrome P450 | |
| Ileum | ILEU | Endoderm | Absorption of products of digestion | Epithelium | 570 | Cell cycle Ribosome Pyrimidine metabolism Antigen processing and presentation | |
| Blood | BLOO | Mesoderm | Supply of oxygen and nutrients | Blood from the femoral vein | 3253 | Hematopoietic cell lineage Regulation of actin cytoskeleton T-cell receptor signalling Focal adhesion ECM receptor interaction Cytokine cytokine receptor interaction Cell adhesion molecules (CAMS) MAPK signalling pathway JAK-STAT signalling pathway Tight junction |
a The complete list is in Supplementary Table S2. See Material and Methods for definition of extreme probe.