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. 2008 Apr 15;22(8):986–991. doi: 10.1101/gad.1621808

Figure 1.

Figure 1.

Fbxw7 is essential to maintain the adult hematopoietic pool. (A) Peripheral blood cell counts of Fbxw7-deficient (red closed circles, n = 15) and control (black closed circles, n = 15) mice after pIpC treatment. Results are shown as means ± SD. Red open circles indicate white blood cell counts of mice developing leukemia. (B) Absolute numbers of MNCs, Lin− cells, and LSK CD34− HSCs in Fbxw7-deficient and control BM at 4, 8, and 12 wk after pIpC treatment. Results are shown as means ± SD from six to eight independent experiments. (*) P < 0.05; (**) P < 0.01.