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. 2008 Apr 15;22(8):986–991. doi: 10.1101/gad.1621808

Figure 3.

Figure 3.

The fate of Fbxw7-deficient hematopoietic cells is determined by p53 expression. (A) Peripheral blood cell counts of Fbxw7-deficient (WBC < 5000, red circle, n = 24; WBC > 5000, blue circle, n = 10) and control (gray circle, n = 13) mice 12 wk after pIpC treatment. Horizontal lines indicate mean values. Closed circles indicate the data for mice that developed leukemia ultimately. (B) Percentage of annexin V-positive apoptotic cells in Fbxw7-deficient (WBC < 5000, red bar; WBC > 5000, blue bar) and control (gray bar) BM MNCs (left) or LSK CD34− HSCs (right) 12 wk after pIpC treatment. Results are shown as means ± SD from four independent experiments. (*) P < 0.05. (C) Western blot analysis of p53 in BM MNCs from control and Fbxw7-deficient mice 4 wk (left) and 12 wk (right) after pIpC treatment. Hsp70 was used as a loading control.