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. 2007 Dec 6;38(5):501–508. doi: 10.1165/rcmb.2007-0298OC

Figure 4.

Figure 4.

Figure 4.

Estrogen receptor antagonist alters AHR in female mice. (A) Effect of daily administration of an estrogen antagonist on AHR in female mice. Open circles, 10 days saline/10 days vehicle; solid circles, 10 days OVA/10 days vehicle; open triangles, 10 days saline/10 days ICI (10 mg/kg/d); solid triangles, 10 days OVA/10 days ICI (10 mg/kg/d). (B) Effect of daily administration of the antagonist in male mice after 10-day OVA inhalation in vivo. Open squares, 10 days saline/10 days vehicle; solid squares, 10 days OVA/10 days vehicle; diamonds, 10 days OVA/10 days ICI (10 mg/kg/d). AHR was assayed 24 hours after the last OVA challenge. ICI182,780 at a dose of 10 mg/kg/d was administered intraperitoneally immediately before each OVA challenge. Results represent the mean ± SEM (n = 8). **P < 0.01 and ##P < 0.01 comparing 10-day saline/10-day vehicle and 10-day OVA/10-day vehicle.