Figure 4.

Airway hyperreactivity. (A) Induction of airway hyperreactivity was measured by assaying airway resistance during graded methacholine (MC) exposure. At each methacholine dose, airway resistance was significantly higher (asterisks) in IL-13–treated WT mice compared with saline-treated mice of either genotype and IL-13–treated GGT^enu1 mice. (B) Airway resistance measured during graded exposure to methacholine was significantly higher in IL-13–treated WT mice (WT_IL13) at all doses compared with saline-treated (WT_sal) and acivicin-treated WT mice (WT_acivicin) (asterisks). The response at 15 μg/ml was significantly attenuated when IL-13 treatment was combined with acivicin (dagger).