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ER stress-induced activation of IRE1-JNK/XBP-1 is blunted in AIP1-KO EC. AIP1-WT and AIP1-KO MLEC were treated with Tm (1 μm) for the indicated times (0, 15, 30, 60, 120, and 240 min). Phosphorylation of IRE1 and JNK and induction of the spliced XBP-1 (a) and phosphorylation of PERK and expression of CHOP (b) as well as total AIP1 andβ-tubulin (c) were determined by Western blot with respective antibodies. ns in b, nonspecific band.
