Table 3.
Frequency of HSV-specific CD8+ pCTL and pProlif in HIV+ patients with severe vs. mild HSV disease
| Severity of HSV disease | n | Median lymphocyte count/μl, range
|
HSV-specific CD8+ pCTL
|
HSV-specific pProlif
|
|||
|---|---|---|---|---|---|---|---|
| CD4+ | CD8+ | Frequency* | Range | Frequency | Range | ||
| HSV-specific CD8+ pCTL | |||||||
| 0–2+ | 8 | 323 (111–570) | 656 (382–1,842) | 1/26,000 | 1/4,000–1/83,000 | ||
| 3+–4+ | 9 | 180 (13–468) | 1,059 (525–1,450) | 1/167,000 | 1/12,000–<1/106 | ||
| HSV-specific pProlif | |||||||
| 0–2+ | 7 | 267 (111–474) | 953 (382–1,842) | 1/3,800 | 1/1,000–1/123,000 | ||
| 3+–4+ | 7 | 246 (50–405) | 1,083 (556–1,450) | 1/6,600 | 1/600–1/142,000 | ||
*
Frequency of CD8+ pCTL in 0–2 vs. 3+–4+, P = .03; all other comparisons not significant (P > .1).