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Megabase-sized hypomethylation zones which contain clusters of tissue-specific genes in tumor cells. As compared with normal breast genome, the 1q23 hypomethylated region is found in the genomes of MCF-7 and primary breast tumor (P < 0.01) and less prominently in MDA-MB-231 genome (P = 0.60). The red horizontal lines represent ratios of one between signals of ExoIII-digested and mock-digested DNA.
