Figure 3.

Distribution of FosB-like proteins in the ventral striatum of wild-type and fosB mutant mice after chronic cocaine treatment. (A, B, D, and E) FosB-like immunoreactivity. (C) Calbindin-like immunoreactivity. (A and D) Saline-treated groups. (B and E) Chronic cocaine-treated groups (20 mg/kg i.p.). (A–C) +/+. (D and E) −/−. ∗, anterior commissure. Arrow in B points at induction of FosB-like proteins. Arrow in C points at the corresponding position in an adjacent section stained with calbindin-D_28K. (Scale bar = 500 μm.)