Figure 2.

Dose-related inhibition of the 2-hr cumulative food intake induced by leptin in presence of CCK in lean mice (+/+) fasted for 24 hr. Leptin was coinjected i.p. with either vehicle, CCK (3.5 μg/kg), or bombesin (5 μg/kg), and mice were immediately exposed to food for 2 hr. Data are expressed as mean ± SEM of 6–12 animals per group. ∗, P < 0.05 vs. the respective leptin alone-treated group or vs. the group receiving CCK alone [ANOVA, F(11,94) = 9.047].