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. 1997 Sep 30;94(20):10588–10593. doi: 10.1073/pnas.94.20.10588

Figure 3.

Figure 3

Activation of LXRα by-products of MVA metabolism. (A) Schematic illustration of the MVA biosynthetic pathway. (B) LXRα is activated by MVA and oxysterols. Cells were transfected as in Fig. 2 and then treated with 7.5 μM mevastatin in the presence of 200 μM MVA, isopentenol, or dimethylallylol; 50 μM geraniol, farnesol, or squalene; 25 μM lanosterol and Chol; 10 μM 20(S)-OH-Chol or 22(R)-OH-Chol. (C) Activation of LXRα by oxysterols. Cells were transfected with the DR4x3 reporter and an LXR expression vector and then treated with 10 μM of the indicated oxysterol or 100 nM LG268.