Figure 1. Effects of chronic inhibition of eNOS activity in the NTS on mean blood pressure (MBP), heart rate (HR) and spontaneous baroreceptor reflex gain (sBRG) in conscious rats.
A significant increase in sBRG was observed 14, 21 and 28 days after the Ad-CMV-TeNOS transfection. In contrast, sBRG did not change in eGFP-transfected and saline-treated groups. In the TeNOS-transfected group, significant decreases in HR were also observed 21 and 28 days post-adenoviral injection. +P < 0.05, ++P < 0.01 and +++P < 0.001 values compared before and after gene transfer. *P < 0.05 and **P < 0.01 values compared to eGFP-transfected group. #P < 0.05 values compared to saline-treated group.