Figure 7. Effect of KB-R7943 on basal [Na⁺]_i, basal [Ca²⁺]_i, speract-induced increases in [Na⁺]_i and [Ca²⁺]_i, and recovery of [Ca²⁺]_i.

KB-R7943 (KB-R) decreased and increased basal [Na⁺]_i (A) and [Ca²⁺]_i (C), respectively; it did not affect the normalized speract-induced increases (Δ; n = 6) in [Na⁺]_i (B) and [Ca²⁺]_i (D), but it slowed the [Ca²⁺]_i recovery. Changes in [Na⁺]_i, and [Ca²⁺]_i induced by speract (100 nm) were measured with SBFI AM(A) and fluo-3 AM (C), respectively, as indicated in Methods, with or without KB-7943 (20 μm).