Table 3.
Effects of Ni2+, Co2+ and aminoglycosides on the properties of pacemaker potentials
| Membrane potential (mV) | Amplitude (primary, mV) | Amplitude (primary, mV) | Frequency (min−1) | Half-width (s) | dV/dtmax(V s−1) | n | |
|---|---|---|---|---|---|---|---|
| Control | −63.2 ± 4.1 | 47.7 ± 5.0 | 49.6 ± 4.1 | 3.2 ± 0.5 | 9.0 ± 0.7 | 0.58 ± 0.17 | 5 |
| Ni2+ 10 μm | −62.3 ± 3.6 | 47.1 ± 4.6 | — | 8.3 ± 0.7** | 3.5 ± 0.1** | 0.50 ± 0.13 | 5 |
| Control | −63.0 ± 3.1 | 47.4 ± 2.6 | 49.5 ± 2.2 | 3.3 ± 0.8 | 7.7 ± 2.2 | 0.63 ± 0.16 | 5 |
| Co2+ 10 μm | −61.7 ± 4.5 | 46.1 ± 4.2 | — | 8.4 ± 1.3** | 2.8 ± 0.4** | 0.56 ± 0.14 | 5 |
| Control | −64.1 ± 2.0 | 47.1 ± 4.5 | 48.6 ± 4.6 | 3.3 ± 0.7 | 8.4 ± 0.8 | 0.48 ± 0.02 | 5 |
| Neomycin 3 μm | −63.1 ± 2.4 | 46.6 ± 4.7 | 48.6 ± 5.2 | 5.8 ± 0.6** | 3.5 ± 1.0** | 0.50 ± 0.08 | 5 |
| Control | −64.3 ± 3.1 | 47.2 ± 3.6 | 48.8 ± 2.8 | 3.3 ± 0.5 | 8.2 ± 1.2 | 0.53 ± 0.08 | 4 |
| Gentamicin 3 μm | −64.4 ± 2.6 | 47.4 ± 3.9 | 48.6 ± 3.6 | 6.2 ± 0.7** | 3.9 ± 0.4* | 0.50 ± 0.09 | 4 |
Values are means ± s.d.n = number of tissues.
*
P < 0.05
**
P < 0.01.