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. 2002 Nov 15;546(Pt 2):387–401. doi: 10.1113/jphysiol.2002.029512

Figure 11. A model of rapid open channel block by quinidine which develops into C-type inactivation.

Figure 11

A, simulated fKv1.4ΔN currents were calculated for a series of depolarising pulses from −90 to +50 mV in 10 mV increments with 2 mm[K+]o. B, currents were recalculated to simulate the block by 100 μm quinidine. Results are shown as peak current-voltage relationships. Currents were normalised to the maximum peak current obtained at +50 mV under control conditions, to enable comparison with experimental data in Fig. 1.