Figure 5. Acute exposure to 10 nm T3 can induce delayed after-depolarizations and spontaneous activity.
A, control recordings show action potential elicited by field stimulation at 1 Hz; T3 induced delayed after-depolarizations that reached threshold to form spontaneous (non-driven) action potentials (*); washout of T3 abolished abnormal activities and returned action potential configuration to control. B, control action potentials elicited by field stimulation at 1 Hz; T3 induced delayed after-depolarizations and spontaneous beats (*); addition of 10 μm ryanodine (Rya) abolished abnormal activities and returned action potential configuration to control.