Figure 4. Effect of niflumic acid on the hyposmosis-induced Ca²⁺ response.

A representative record for 9 cells shows that niflumic acid (300 μm), an inhibitor of the swelling-activated chloride channel, prevented the Ca²⁺ response to a reduction in osmotic concentration from 300 to 250 mosmol kg⁻¹. In two other cells the drug did not prevent the Ca²⁺ response, but strongly reduced it.