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. 2002 Dec 6;546(Pt 3):665–675. doi: 10.1113/jphysiol.2002.033803

Figure 4. Heterosynaptic modulation of TA–CA3 synaptic transmission by MF inputs.

Figure 4

MF (open circles, n = 8) or AC (closed circles, n = 5) was stimulated (each 1 pulse at 300 µA) prior to TA stimulation. The ordinate indicates the ratio of TA-evoked fEPSPs following MF/AC stimulation to control fEPSPs without the prior conditioned stimulus. When the MF stimulus was immediately preceded by TA activation, TA–CA3 transmission was significantly depressed. The depression occurred as a function of the time by which the MF stimulus precedes the TA stimulus. The AC stimulus was virtually ineffective. Representative field potentials with (each lower trace) or without (each upper trace) the conditioned stimulus at an inter-pulse interval of 40 ms are shown in the inset. **P < 0.01vs. no conditioned stimulus. Data represent means ± s.e.m. of n cases.